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??????Coronaviruses, named after their crown-like shape, were first identified in the 1960s and are associated with a range of respiratory symptoms. Cases such as Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) can cause aggravated symptoms in humans and can lead to pneumonia, severe acute respiratory syndrome and death1,2?. SARS-CoV-2 (formally known as 2019-nCoV) is the latest coronavirus strain to be identified. ??
Chinese scientists identified the novel coronavirus as a group 2B CoV, distinct from the SARS-CoV3,4,5. Genome sequencing demonstrated that SARS-CoV-2 (2019-nCoV) shares 79.5% sequence identity with SARS-CoV and 96% of identity with a bat coronavirus6.
To access host cells, coronaviruses attach to specific host cellular receptors via the spike protein7. Thus, SARS-CoV utilizes angiotensin converting enzyme II (ACE-2) host cell receptor whereas MERS-CoV uses CD26 (DPP4)8. The results of several recent studies suggest that SARS-CoV-2 can use the same cell entry receptor, ACE-2, as SARS-CoV6,9,10.
At the time of publishing this page, no vaccine or specific antiviral treatment exists for SARS-CoV-2. Scientists are searching for potential vaccines and therapeutic agents targeting SARS-CoV-2 or host cell components (eg host cell receptors) necessary for viral replication.
Abcam offers a variety of tools used to help understand and accelerate infectious disease research, including coronavirus (SARS-CoV-2). To help researchers navigate quickly to relevant products, listed below are antibodies and proteins specific for human coronavirus and cytokine detection products for human coronavirus research.
|Human ACE2 ELISA Kit||ab235649||ELISA||Human|
|Mouse ACE2 ELISA Kit||ab213843||ELISA||Mouse|
|Human ACE2 Antibody Pair - BSA and Azide free||ab244135||ELISA||Human|
|ab87436||ICC/IF, IHC-P, WB||Human (predicted: Mouse, Rat, Hamster, Cat, Dog, Orangutan)|
|Recombinant Anti-ACE2 antibody [EPR4435(2)]||ab108252||IHC-P, IP, WB||Mouse, Rat, Human|
|Recombinant Anti-ACE2 antibody [EPR4435(2)] - BSA and Azide free|
IHC-P, IP, WB
Mouse, Rat, Human
|Anti-ACE2 antibody - N-terminal||ab228349||IHC-P, WB||Mouse, Human (predicted: Rhesus monkey)|
Anti-IL-1 beta antibody
|ab9722||WB, ELISA, Neutralising, IHC-P, ICC, IHC-Fr, IHC-FoFr, ICC/IF||Mouse, Rat, Human|
|Human IL-2 ELISA Kit||ab174444||ELISA||Human|
|Human IL-6 ELISA Kit||ab178013||ELISA||Human|
|Anti-IL-6 antibody||ab9324||ICC/IF, IHC-Fr, IHC-P, Neut, sELISA, WB||Rat, Human|
|Anti-IL-17 antibody||ab79056||ELISA, ICC/IF, IHC-Fr, IHC-P, WB||Mouse, Dog, Human|
|Human IFN gamma ELISA Kit||ab174443||ELISA||Human|
|Anti-Interferon gamma antibody||ab9657||ICC/IF, IHC-P, Neut, sELISA, WB||Mouse, Human, Macaque monkey|
|Anti-IP10 antibody||ab9807||ELISA, IHC-Fr, IHC-P, Neut, WB||Human|
|Human TNF alpha ELISA Kit||ab181421||ELISA||Human|
|Anti-TNF alpha antibody||ab6671||ELISA, ICC/IF, IHC-P, WB||Human, Cynomolgus monkey|
|Human VEGF ELISA Kit||ab222510||ELISA||Human|
|Anti-VEGFA antibody [VG-1]||ab1316||ELISA, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB||Mouse, Rat, Rabbit, Dog, Human|
|Anti-VEGFA antibody [EP1176Y] - C-terminal||ab52917||Flow Cyt, ICC/IF, IHC-P, IP, WB||Mouse, Human|
See a complete list of cytokine products for your research.
If you are interested in the commercial use of our products, please connect with us at email@example.com.
For the latest information on the outbreak, please visit the World Health Organization (WHO) website.
3.Virological.org. Novel 2019 Coronavirus Genome. Available online: http://virological.org/t/novel-2019-coronavirus-genome/319 (accessed on 28 January 2020).
4. GSAID Database. 2020 Coronavirus. Available online: https://www.gisaid.org/CoV2020/ (accessed on 28 January 2020).